From 0808b4a65f30069e1530ca4b9db7b046e5aa3ea2 Mon Sep 17 00:00:00 2001
From: ackman678 <james.ackman@gmail.com>
Date: Thu, 29 Sep 2016 15:24:11 -0700
Subject: [PATCH] lecture03 post

---
 2016-09-28-lecture03.md | 53 +++++++++++++++++++++++------------------
 1 file changed, 30 insertions(+), 23 deletions(-)

diff --git a/2016-09-28-lecture03.md b/2016-09-28-lecture03.md
index 157c703..1ee0ceb 100644
--- a/2016-09-28-lecture03.md
+++ b/2016-09-28-lecture03.md
@@ -24,18 +24,18 @@ as well as general molecular signaling within neurons as any living cell might h
 
 ---
 
-## Neurons have a negative membrane potential at rest.
+## Neurons have a negative membrane potential at rest
 
-<div style="font-size:0.7em">
+<div style="font-size:0.7em; width:600px">
 <div></div>
 
 * For intracellular recordings, an electrode is placed inside a cell such that the inside of the pipette is contiguous with the inside of the cell. If this electrode is connected to a voltmeter, which records transmembrane voltage across the cell membrane, one can determine the difference in voltage between the inside and outside of the cell. 
 * When one does this in neurons, the microelectrode reports a negative potential called the resting potential. Always a fraction of a volt (-40 to -90 mV).
-* Volts are a unit of electrochemical potential energy. 1 Volt will drive 1 coulomb of charge (6.24X10<sup>18</sup> electrons) through a resistance of 1 ohm in 1 second.
+* Volts are a unit of electrochemical potential energy. 1 Volt will drive 1 coulomb of charge (6.24x10<sup>18</sup> electrons) through a resistance of 1 ohm in 1 second.
 
 </div>
 
-<div><img src="figs/2016-01-1112.07.56_fad9e4d.jpg" height="100px"><figcaption></figcaption></div>
+<div style="margin:0 15px;"><img src="figs/neuron_model-oscilloscope_a84cec9.png" width="300px"><figcaption></figcaption></div>
 
 Note:
 
@@ -58,7 +58,7 @@ Pipe diameter ~ Resistance (ohms) = `R`
 
 Flow rate ~ Current (amperes) = `I`
 
-`V = IR` Ohm’s law
+`V = IR` **Ohm’s law**
 
 `I = V/R`
 
@@ -130,14 +130,20 @@ This figure shows these 3 types of neuronal signals.
 
 ---
 
-## Resting Potentials of Neurons
+## Resting membrane potential of neurons
+
+<div style="font-size:0.9em;">
+<div></div>
 
 * The membrane of a nerve cell maintains an electrical polarization
-* The cell is polarized: at rest, an electrical gradient is maintained across the plasma membrane (negative charge is greater inside the cell)
-* The cell has a resting potential: difference in voltage across the membrane of a cell (~ -70 mV)
-* The cell has a concentration gradient: difference in distribution of ions between the inside and outside of a membrane 
+* The cell is polarized– at rest, an electrical gradient is maintained across the plasma membrane (negative charge is greater inside the cell)
+* The cell has a resting potential– difference in voltage across the membrane of a cell (~ -70 mV)
+* The cell has a concentration gradient– difference in distribution of ions between the inside and outside of a membrane 
+
+</div>
+
+<div><img src="figs/lipid_bilayer_519d59a.png" height="200px"><figcaption></figcaption></div>
 
-<div><img src="figs/image_f9eaff2.png" height="100px"><figcaption></figcaption></div>
 
 
 Note:
@@ -252,7 +258,7 @@ There are also ion channels that form pores in the cell membrane that are select
 * Requires ATP
 * Helps set up the ion concentration gradients and resting membrane potential
 
-<div><img src="figs/alberts_fig11-10-NaKatpase_f8e7b70.png" height="300px"><figcaption>Alberts *Mol Biol of the Cell* Fig. 11-10</figcaption></div>
+<div><img src="figs/alberts_fig11-10-NaKatpase_f8e7b70.png" height="300px"><figcaption>Alberts *Mol Biol of the Cell* 3e Fig. 11-10</figcaption></div>
 
 
 Note:
@@ -268,7 +274,8 @@ Here is one these ion transporters— the Na-K pump that moves 3 Na out of the c
 * Show ion selectivity
 * Can be gated by different mechanisms
 
-<div><img src="figs/image2_e205b47.png" height="100px"><figcaption></figcaption></div>
+<figure><img src="figs/lipid_bilayer_c8a3c0c.png" height="200px"><figcaption></figcaption></figure>
+
 
 Note:
 
@@ -446,17 +453,6 @@ T = 20+273
 ==>58.26427
 
 
----
-
-## Electrochemical equilibrium video
-
-<div><video height=400px controls src="figs/Animation02-02ElectrochemicalEquilibrium.mp4"></video><figcaption>Neuroscience 5e Animation 2.2</figcaption></div> 
-
-
-Note:
-
-
-
 ---
 
 ## Examples
@@ -512,6 +508,17 @@ I = g(Vm-Ex).  g = conductance, no. of open channels. (Vm-Ex) = driving force ca
 
 ---
 
+## Electrochemical equilibrium video summary
+
+<div><video height=400px controls src="figs/Animation02-02ElectrochemicalEquilibrium.mp4"></video><figcaption>Neuroscience 5e Animation 2.2</figcaption></div> 
+
+
+Note:
+
+
+---
+
+
 ## Membrane potential influences ion fluxes
 
 <figure><img src="figs/Neuroscience5e-Fig-02.06-1R_5d1ff2f.png" height="500px"><figcaption>Neuroscience 5e Fig. 2.6</figcaption></figure>