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neurophys4

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2021-10-14 19:59:22 -07:00
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neurophysiology1.md
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@@ -784,7 +784,7 @@ Note:
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## K⁺ concentration gradient determines resting membrane potential
## K⁺ concentration gradient largely determines resting membrane potential
<figure><img src="figs/Neuroscience5e-Fig-02.08-0_40bc007.png" height="400px"><figcaption>
@@ -799,7 +799,7 @@ They plotted resting membrane potential against the extracellular K⁺ concentra
If internal K⁺ is unchanged, a plot of membrane potential against the log of external K⁺ concentration would yield a straight line with slope of 58mV per tenfold change in external K⁺ concentration at RT.
However it deviates from this expected relationship (shown by the black line), especially at lower K⁺ concentrations. Why is this?
However it deviates from this expected relationship (shown by the black line), especially at lower K⁺ concentrations. Why?
**Because other ions, particularly Cl⁻ and Na⁺, are also slightly permeable and the contribution of these other ions is more evident at low K⁺ concentrations.**
@@ -915,13 +915,14 @@ And as we will soon learn, the resting membrane potential and action potential v
## The action potential– summary
<figure><img src="figs/action_potential_ab5134f.png" width="800px"><figcaption></figcaption></figure>
<figure><img src="assets/fig_AP.svg" width="800px"><figcaption></figcaption></figure>
Note:
And this is just a overall summary of what we have been discussing
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## Action potential form and nomenclature
@@ -937,16 +938,13 @@ AHP due to voltage-gated K⁺ channels, including Ca²⁺ activated potassium ch
## Action potential forms
<div><figcaption class="big">(1) Frog motor neuron cell body, (2) guinea pig inferior olive neuron cell body, (3) cell body of purkinje neuron</figcaption><img src="figs/Neuroscience5e-Box-02C-0-2_f48aa34.png" width="800px"><figcaption>Neuroscience 5e Box 2C</figcaption></div>
Summation of many spikelets cause unlike most neurons, purkinje cells in cerebellum have dendrites that can initiate action potentials. The dendrites aren’t myelinated.
Summation of many spikelets, cause unlike most neurons, purkinje cells in cerebellum have dendrites that can initiate action potentials.
Llinas Sugimori J Physiol 1980 Purkinje neurons