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@@ -285,4 +285,65 @@ Connor Nature 2005, N&V on Quiroga et al:
sparse and non-variant
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## Short-term plasticity of the gill-withdrawal reflex in sea slugs
Facilitation in the marine mollusk *Aplysia californica*
<div><img src="figs/Neuroscience5e-Fig-08.03-1R_copy_3f9f1c7.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.3</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-08.03-2R_copy_2b59a30.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.3, Squire and Kandel 1999</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-08.03-3R_copy_0fbd016.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.3, Squire and Kandel 1999</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-08.03-4R_copy_784bb55.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.3, Squire and Kandel 1999</figcaption></div>
Note:
Squire and Kandel. *Memory: From Mind to Molecules* 1999
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## Epilepsy
Disorder characterized by periodic seizures from synchronous firing of large groups of neurons in the nervous system. Kindling and synaptic plasticity plays a role.
<figure><img src="figs/Neuroscience5e-Box-08C-0_57467fe.jpg" height="100px"><figcaption>Neuroscience 5e Box 8C, Dyro 1989</figcaption></figure>
Reid et al., Prog Neurobiol 2009
Scheffer adn Berkovic Trends Pharm Sci 2003
McNamara et al., STKE 2006
Engel 2008, *Epilepsy: A Comprehensive Textbook*
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## Synaptic mechanisms of short-term sensitization in sea slugs
<div><img src="figs/Neuroscience5e-Fig-08.04-1R_copy_840c43d.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.4</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-08.04-2R_copy_7c288a4.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.4, Squire and Kandel 1999</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-08.04-3R_copy_9e8b3eb.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.4, Squire and Kandel 1999</figcaption></div>
Note:
Squire and Kandel. *Memory: From Mind to Molecules* 1999
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## Molecular signals underlying short- and long-term sensitization in *Aplysia*
<div><img src="figs/Neuroscience5e-Fig-08.05-1R_copy_1739967.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.5, Squire and Kandel 1999</figcaption></div>
<div><figcaption class="big">persistent PKA (green)
unindentified proteins responsible for synaptic growth (yellow)
</figcaption><img src="figs/Neuroscience5e-Fig-08.05-2R_copy_2b6b868.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.5, Squire and Kandel 1999</figcaption></div>
Note:
Squire and Kandel. *Memory: From Mind to Molecules* 1999
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## CamKII signaling in a dendritic spine during LTP
<div><img src="figs/Neuroscience5e-Fig-08.11-1R_d67561b.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.11</figcaption></div>
<div><img src="figs/Neuroscience5e-Fig-08.11-2R_f40021e.jpg" height="100px"><figcaption>Neuroscience 5e Fig. 8.11, Lee et al., *Nature* 2009</figcaption></div>
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