59 lines
2.7 KiB
Markdown
59 lines
2.7 KiB
Markdown
# wholeBrain imaging paper
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The goal of this work is to provide a broad description of the population activity patterns that occur in developing cerebral cortex.
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The main manuscript file is **[wholeBrain_main.md][]**
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## Rationale
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The idea is to provide a clear and beautiful representation of the visualized activity patterns in the developing brain.
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### Scientific importance
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A comprehensive description of the spatiotemporal activity patterns in the immature brain will be crucial to understanding the developmental dynamics that exist between intrinsic and extrinsic factors that regulate circuit development.
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* signature patterns that predict current or future behavior
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* construction of self-organizing circuits (advanced robotics -- *Terminator, Skynet, Cylons*)
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### Human health importance
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* neurodevelopmental disorders (autism, schizophrenia, epilepsy)
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* activity-dependent structural plasticity. Implications for brain repair.
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* development of brain-machine interfaces
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### Future work
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More detailed descriptions of the nature and the functions of these activity patterns can and should be performed in parallel in ongoing and future studies.
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For example:
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* What is the intra- vs sub- cortical nature of barrel cortex activity (E.M.'s work)
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* What is the intra- vs sub- cortical nature of ongoing activity in motor- associational-, and other non-primary sensory cortical areas?
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* Relationship of imaged patterns to EEG patterns described in other studies?
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* Extent to which functional correlations reflect direct synaptic connections?
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* Retinal wave drive of other areas?
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* Ontogenetic relationships of localized calcium domains?
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* Development profile through first postnatal weeks
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* Chronic developmental profile in individuals?
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* Aberrant activity patterns in developmental disorder and seizure models?
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## Workflow
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Writing workflow will be similar to that used previously for [current opinion review][id3]. Some useful info in [currOpinRvw outline][id2].
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Instructions for [converting multimarkdown to Word document][id4]
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Image processing and dataset generation will utilize custom code in the [wholeBrainDX] software project.
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Datasets, and exploratory data analysis will use R code that lives inside this wholeBrain project repository. Datasets and raw data to big too be inside this git repo will be stored on external servers and linked to accordingly.
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[wholeBrain_main.md]: wholeBrain_main.md
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[id2]: https://github.com/ackman678/currOpinRvw/blob/master/currOpin_outline.md
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[id3]: https://github.com/ackman678/currOpinRvw/blob/master/README.md
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[id4]: https://gist.github.com/ackman678/6391902
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[wholeBrainDX]: https://github.com/ackman678/wholeBrainDX/blob/master/README.md
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